Molecular biology has developed more than any other branch of science in recent years. Advances in molecular biology and cell biology have provided us with an understanding of the mechanisms of disease at the molecular level. Molecular Biology in Public health or Public health biotechnology (PHB) covers current molecular biological techniques, which can be used to identify the underlying molecular processes in inherited disease as well as a wide variety of health-related conditions. This understanding can now be translated into diagnostic, therapeutics, prognosis and prevention. It is apparent that this growing field of molecular diagnostics is an important factor in advanced patient care.

Objectives

  1. To improve the necessary theoretical and practical background for appropriate use of molecular/biotechnological tools in public health
  2. To prepare candidates found to be suitable for higher academic degree in Public Health Biotechnology for the attainment of the same.

 

Admission Requirements

Holders of medical degree (MBBS/BDS or equivalent) certificate of the University of Ibadan or other Universities recognized by the senate of the University. A good honours degree (minimum of second class lower division) in the basic and Medical Sciences: Chemistry, Zoology, Biology, Microbiology, Biochemistry, Physiology, Nursing, Physiotherapy or other Allied health professionals and graduates of other relevant courses to Public Health Technology of the University of Ibadan or other Universities recognized by the Senate of the University of Ibadan.  Candidates must satisfy the normal University of Ibadan basic and higher degree requirements for matriculation


Main Courses from ICH

  1. CHH 707 Child Health Communicable Diseases I

Diagnosis, management, prevention and social interplay in disease outcome to be stressed: Tuberculosis; Diphtheria, Pertussis, Tetanus; Measles, Chicken pox, Rubella; Poliomyelitis; Malaria; HIV/AIDS; Diarrhoeal Diseases; Helminthic Infections

 

  1. CHH 708 Child Health II: Common Non-communicable Systemic Diseases

Diagnosis, management, prevention and social         interplay in disease outcome to be stressed: Poisoning and home accidents; Respiratory; Gastrointestinal disorders; Congenital Cardiac Problems; Acquired Cardiac Problems; CNS Disorders; Metabolic and Endocrine; Tumours of Childhood; Disorders of the Urogenital system

 

  1. CHH 721 Genetics in Health and Disease

Principles of Mendelian Inheritance: Pattern of single gene traits in human, multifactorial inheritance, sex determination; Twinning; genetic aspects of human development; Molecular basis of cancer – Malignancies; Chromosomal rearrangements; Genetic Aberrations that result in genetic diseases, Genetic testing in individuals and in population and genetic counseling; Human genome: HapMap, 1000 genome study, GWAS and application to Clinical Medicine; Functional genomics and proteomics; New approaches to treating disease

 

  1. CHH 722 Molecular Biology/Genetics

DNA structure and gene expression; Gene regulation; Chromosome structure and function; Aspects of chromosomal activation and deactivation; Cells and development; Gene in pedigree and population; Amplifying DNA (cloning etc); Analysing DNA structure, variation and expression (sequencing and genotyping: Repeat sequences and distributions Expressed Sequence Tags (EST), Single nucleotide polymorphism (SNPs)); Genome projects and model organisms; Organization of the human (genome copy number variations, mutation and DNA repair), anopheles and Plasmodium genomes; Mapping and identifying disease genes and mutation (recombinant DNA/ genetic markers); Molecular Pathology

 

  1. CHH 724 Molecular Diagnostics/Pathology

Advanced Cytogenetics (Chromosomes: evolution, structure and function, karyotyping and analysis, aberrations and associated syndromes; Polyploidy and evolution in animals) Principles of Molecular Biotechnology: Molecular biotechnology of biological systems (DNA, RNA, Protein synthesis, PCR techniques; Manipulation of gene expression, directed mutagenesis; Molecular biotechnology of microbial systems (therapeutic agents, Vaccines); Molecular biotechnology of Eukaryotic systems (human molecular genetics, gene therapy); Reagent development; Molecular epidemiology; Molecular Techniques (methods in diagnosis of parasitic infections; Methods in malaria research (Basic Microscopy –Flow cytometry – counting different cell types; Immunology, ELISA, developing assays for phagocytosis, cell adhesion etc)

 

  1. CHH 732 Basic Immunology in Childhood Diseases

Introduction to Immunology: Antigens (Immunogens) and the immune response, fate of antigens, functions; The lymphoid system; Anaphylactic reactions – antibody and cell mediated types, tests for cellular immune responses; Diagnostic immunological tests; Autoimmunity; Immunodeficiency states; Immunoproliterative disorders; immunological tolerance and immunosuppression; The major histocompatibility systems and transplantation reactions; Immune complex diseases; Immunity to tropical parasitic infections; viral immunology; Immunology of protein calorie malnutrition; tumour immunology and immunohaematology; Antigen processing; Reproductive immunology; Immunotoxicology

 

  1. CHH 726 Bioinformatics

Introduction to BioInformatics (Data Model – the NCBI example, GeneBank Sequence Database, Structure databases); Genomic Mapping and Mapping Databases (Genomic map Elements); Information Retrieval (Locus link and integrated information retrieval, Medical and Public Health databases, Sequence Alignment methods and gap penalties, statistical significance, FASTA, BLAST Artefacts scoring matrices and Spliced Alignments); Genomics (Genome Analysis, Comparative genomics).

 

  1. CHH 727 Genetic Epidemiology of communicable and non-communicable diseases

Etiology, distribution, and control of communicable disease relevant to the tropics in groups of relatives and with inherited causes of disease in populations; Molecular epidemiology (contribution of potential genetic and environmental risk factors to etiology):discussions and case studies (For example, Malaria, Respiratory diseases, Viral diarrhea, Measles, Tuberculosis, Neglected Tropical diseases (NTDs), HIV) Etiology, distribution, and control of non-communicable disease relevant to the tropics in groups of relatives and with inherited causes of disease in populations; Molecular epidemiology (contribution of potential genetic and environmental risk factors to etiology): discussions and case studies (For example, Diabetes, Hypertension, Obesity, Stroke and Cancer)

 

  1. CHH 729 Advanced Statistical methods in Genetic epidemiology

Overview of genetic epidemiology (descriptive epidemiology and hypothesis generation); Basic epidemiology and statistical principles (basic probability theory, basic epidemiology principles); familial aggregation; segregation analysis; linkage analysis; testing Candidate gene association; linkage equilibrium mapping; Genome Wide Association studies and analysis (GWAS); gene characterization.

 

  1. CHH 730 Aetiopathogenesis of Communicable and Non-Communicable diseases

The cause and development of a disease: The causative agents (genetic, metabolic, physiology) and environmental factors (treatment, drug resistance); development of the disease (host factors (genetic, metabolic, physiology) associated with the onset and subsequent development; Case studies and discussions (Malaria, Respiratory diseases, Viral diarrhea, Measles, Tuberculosis, Neglected Tropical diseases (NTDs), HIV); Case studies and discussions (Diabetes, Hypertension, Obesity, Stroke and Cancer)

 

  1. CHH 705 Research Project

A research project with specific application of biotechnology to a particular disease

 

  1. CHH 732 Seminar

A critical review of current literature on topics related to the application of biotechnology to Public health

 

Courses from other Departments

  1. ZOO 794 Environmental Mutagens

Interaction between gene and environment; Mutagens and carcinogens; Mechanisms of mutagenesis; Genetic factors in the response to mutagens; Genetic risks to man with particular reference to the tropical environment; DNA repair mechanism; Assays for evaluating integers; Toxicogenomics

 

  1. ZOO 796 Population and Quantitative Genetics

Sampling techniques; Genetic markers and biometric traits; Gene and     genotypic frequencies in natural populations; Mating systems, gene pools and natural selection; Analysis of genetic variation; Genetic polymorphisms

 

  1. EMS 722 Principles of Epidemiology

History of Epidemiology; Definitions, basic principles, uses and application of epidemiology; Introduction to epidemiological studies; Inferential epidemiology and statistics; Notification and Surveillance; Evaluation of diagnostic and screening tests, (specificity, sensitivity, validity and predictive values); Concepts of Association and Causation; Epidemics and Epidemic curves; Burden of diseases

 

  1. EMS 727 Basic Statistical Procedure

Roles of statistics and human biology and medicine; Revision of basic concepts of probability and descriptive statistics; Significance tests methods based on normal distribution; ANOVA, Covariance; Regression and correlation, Confidence intervals, formal and informal tests of assumption tests for discrete data; Contingency tables; Basic distribution of free methods; Man Whitney, Sign test, Spearman Kendall Correlations, Kruskall Wallies Test

 

  1. EMS 729 Computer in Medicine

Computer hardware, peripherals and communication; Data acquisition and principles of information storage; Statistical packages for data management and analysis;Introduction to Epi Info, Word Perfect, MS-Word, SAS-PC; Design of computer and data management systems; Principles of data management.

 

  1. HPE 714 Ethics in Public Health Research

Need for ethical review of research projects. Procedures for ensuring ethical clearance of projects. Informed consent. Guideline for setting up ad managing institutional review boards. Conduct and misconduct in research. Conflicts of interest in research